Cell Dynamics Lab

Morphogenesis,
from molecule to tissue

Publications

Developmental Cell cover: The image shows three stages in the epidermal zippering process that completes neural tube closure in a basal chordate, Ciona intestinallis. Staining F-actin with fluorescent phalloidin highlights the apical surfaces of the epidermal cells that undergo zippering. Active junction contractions just ahead of the zipper plus junctional rearrangement and cell detachment just behind the zipper create an imbalance of force that pulls the neural fold together and drives the zipper forward. See Hashimoto, Robin et al for a detailed analysis of the zippering mechanism that combines experiments with computer modeling.

Costache V, Prigent Garcia S, Plancke CN, Li J, Begnaud S, Suman SK, Reymann AC, Kim TY✉, Robin FB✉, Rapid assembly of a polar network architecture drives efficient actomyosin contractility, Cell Reports, 2022 May 31;39(9):110868. doi: 10.1016/j.celrep.2022.110868. biorXiv. PDF1 PDF2

Bidaud-Meynard A, Demouchy F, Nicolle O, Pacquelet A, Suman SK, Plancke CN, Robin FB, Michaux G. High-resolution dynamic mapping of the C. elegans intestinal brush border, Development, 2021 Dec 1;148(23):dev200029. doi: 10.1242/dev.200029. Epub 2021 Dec 10. PMID: 34704594. PDF

Robin FB, Van Gorp A✉, Veber A. The role of mode switching in a population of actin polymers with constraints, Journal of Mathematical Biology, 2021 Feb 1;82(3):11. doi: 10.1007/s00285-021-01551-z. PMID: 33527236. Authors in alphabetical order, as per standards in the field. PDF

Suman SK, Daday C, Ferraro T, Vuong-Brender T, Tak S, Quintin S, Robin FB, Gräter F, Labouesse M, The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis, Development. 2019 Dec 13;146(24):dev183780. PDF

Michaux JM*, Robin FB*✉, McFadden WM, Munro EM✉. Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo, J Cell Biol. 2018 Dec 3;217(12):4230-4252.PDF
*: authors contributed equally
✉: corresponding authors

Quintin S, Wang S, Pontabry J, Bender A, Robin F, Hyenne V, Landmann F, Gally C, Oegema K, Labouesse M, Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation. Development. 2015 Nov 19. pii: dev.126615.PDF

Hashimoto H*, Robin FB*✉, Sherrard KM, Munro EM✉, Sequential contraction and exchange of apical junctions drives zippering and neural tube closure in a simple chordate, Dev Cell. 2015 Jan 26;32(2):241-55.PDF
*: authors contributed equally
✉: corresponding authors
Cover and paper featured as Article+

Robin FB, McFadden WM, Yao B, Munro EM. Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos. Nat Methods. 2014 Jun;11(6):677-82.PDF

Robin FB, Dauga D, Tassy O, Sobral D, Daian F, Lemaire P, Time-lapse imaging of live Phallusia embryos for creating 3D digital replicas, Cold Spring Harb Protoc. 2011 Oct 1;2011(10):1244-6.PDF

Robin FB, Dauga D, Tassy O, Sobral D, Daian F, Lemaire P, Imaging of fixed ciona embryos for creating 3D digital replicas, Cold Spring Harb Protoc. 2011 Oct 1;2011(10):1247-50.PDF

Robin FB, Dauga D, Tassy O, Sobral D, Daian F, Lemaire P, Creating 3D digital replicas of ascidian embryos from stacks of confocal images, Cold Spring Harb Protoc. 2011 Oct 1;2011(10):1251-61.PDF

Tassy O*, Dauga D*, Daian F*, Sobral D*, Robin F, Khoueiry P, Salgado D, Fox V, Caillol D, Schiappa R, Laporte B, Rios A, Luxardi G, Kusakabe T, Joly JS, Darras S, Christiaen L, Contensin M, Auger H, Lamy C, Hudson C, Rothbächer U, Gilchrist M, Makabe MW, Hotta K, Fujiwara S, Satoh N, Satou Y and Lemaire P, The ANISEED database: digital representation, formalization and elucidation of a chordate developmental program, Genome Res. 2010 Oct;20(10):1459-68.PDF
*: authors contributed equally

Sherrard K*, Robin F*, Edwin Munro and Patrick Lemaire, Sequential activation of apical and basolateral contractility drives ascidian endoderm invagination, Curr Biol. 2010 Sep 14;20(17):1499-510.PDF with 3d models (last page). Check it out!
*: authors contributed equally

Roure A, Rothbächer U, Robin F, Kalmar E, Ferone G, Lamy C, Missero C, Mueller F, Lemaire P, A multicassette Gateway vector set for high throughput and comparative analyses in ciona and vertebrate embryos, PLoS ONE. 2007 Sep 19;2(9):e916.PDF

Munro E, Robin F, Lemaire P, Cellular morphogenesis in ascidians: how to shape a simple tadpole, Curr Opin Genet Dev. 2006 Aug;16(4):399-405.PDF

IBPS - Laboratoire de Biologie du Développement – ERL 1156
CNRS – Université Pierre et Marie Curie – Inserm
9, quai Saint-Bernard – Bât. C – 6ème Et. – Case 24 – 75252 Paris cedex 05 – France
Tel :+33 (0)1 44 27 42 41 – email : francois.robinATupmc.fr